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03.019.0.01.014.00.044.002. SARS coronavirus isolate HKU-36871

Cite this publication as: Sara Mullins for ICTVdB Management (2005). 03.019.0.01.014.00.044.002. SARS coronavirus isolate HKU-36871. In: ICTVdB - The Universal Virus Database, version 3. Büchen-Osmond, C. (Ed), ICTVdB Management, Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 3. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Table of Contents

Isolation Details

Isolate designation: HKU-36871.
Isolation date: 28 February; 2003.
Location: Patient traveled to Guangzhou for two days, then presented with symptoms 5 days after returning to Hong Kong; infection most likely occurred in Guangzhou; Hong Kong; Hong Kong.
Source of isolate: human.

Virus was isolated by Dr J.S. Malik Peiris; Department of Microbiology; University of Hong Kong; Pokfulam Rd; Hong Kong, Special Administrative Region; China. Email: malik@hkucc.hku.hk. Involved in the submission of the isolate was also F.C. Leung, Ph.D; Department of Zoology, University of Hong Kong, Hong Kong SAR, China; Y. Guan, Ph.D; Department of Microbiology, University of Hong Kong, Hong Kong SAR, China; F.Y. Zeng, Ph.D; Department.

Reference: Guan Y, Peiris JS, Zheng B, Poon LL, Chan KH, Zeng FY, Chan CW, Chan MN, Chen JD, Chow KY, Hon CC, Hui KH, Li J, Li VY, Wang Y, Leung SW, Yuen KY, Leung FC (2004) Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome, The Lancet, 363, 99-104. PubMed ID to this reference is [14726162].

Classification

This is a description of a vertebrate virus at the isolate level.

ICTVdB Virus Code: 03.019.0.01.014.00.100.002. Virus accession number: SARSI034. Former accession number: 40EAEC66. NCBI Taxonomy ID: [231519].

Biocontainment Level

Distribution of this virus falls under quarantine restrictions. It is recommended to handle this virus at the biocontainment level BSL-3.

Name, Synonyms and Lineage

Synonym(s): HKU-36 PMID: 14726162. Virus is assigned to strain   HKU-36; species   SARS coronavirus. Virus is assigned to the genus 03.019.0.01. Coronavirus , family 03.019. Coronaviridae , order 03. Nidovirales.

Depositories and Collections

The isolate has been deposited at an institution at University of Hong Kong.

Virion Properties

Introduction

Particles contain nucleic acid. { } Nucleic acid of virions is encapsidated.

Virion Properties

Morphology

Virions consist of an envelope, spikes, and a nucleocapsid. Virus capsid (core) is enveloped.

Nucleic Acid

The genome is not segmented and consists of a single molecule of linear, positive-sense, single-stranded RNA. The RNA has been partially sequenced; sequence can be accessed at GenBank with the accession number [AY304492]. Reference to nucleotide sequence PubMed ID: [12958366].

Biological Properties

Natural Host Range

Viral hosts belong to the Domain Eucarya.

Domain Eucarya Kingdom Animalia.

Kingdom Animalia Phylum Chordata.

Phylum Vertebrata Subphylum Vertebrata.

Class Mammalia.

Class Mammalia Order Primates;
Family Hominidae; virus infects Homo sapiens (human).

Host and isolation details Virus was isolated from an adult. Virus was isolated from nasopharyngeal aspirate.

General Symptoms in Animals Infection can affect the respiratory system, hematopoiesis, and gastrointestinal system. General symptoms include fever. Signs and symptoms include crepitations upon lung auscultation with corresponding alveolar shadow; diarrhea; leukopenia and thrombocytopenia.

Severity and Occurrence of Disease

Host 1: Infection is apparent and clinically expressed.

References

Guan Y, Peiris JS, Zheng B, Poon LL, Chan KH, Zeng FY, Chan CW, Chan MN, Chen JD, Chow KY, Hon CC, Hui KH, Li J, Li VY, Wang Y, Leung SW, Yuen KY, Leung FC (2004) Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome, The Lancet, 363, 99-104.

Contributor

Data have been submitted online to ICTVdB on 01-12-05 by
Sara Mullins
American Type Culture Collection
George Mason University
PW II, 10801 University Boulevard
Manassas, VA 20110
United States of America
Tel: + 703-365-2700.
Fax: + 703-365-2701.
Email: Sara Mullins.

DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

ICTVdB and DELTA related References

Last updated:15 March 2005 by Cornelia Büchen-Osmond
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