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03.019.0.01.014.00.000.002. SARS-Coronavirus FRA

Cite this publication as: Sara Mullins for ICTVdB Management (2005). 03.019.0.01.014.00.000.002. SARS-Coronavirus FRA. In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), ICTVdB Management, Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Table of Contents

Isolation Details

Isolate designation: FRA.
Isolation date: 16 March; 2003.
Location: not specified.
Source of isolate: human.

Virus was isolated by Prof Dr Hans Wilhelm Doerr; Insitute for Medical Virology, University hospital of Frankfurt am Main, Paul Ehrlich Str. 40, 60506 Frankfurt Main, Germany. Email: H.W.Doerr@em.uni-frankfurt.de. Involved in the submission of the isolate was also Dr. Hans-Dieter Klenk; Institut fuer Virologie, Robert-Koch-Str. 17, 35037 Marburg, Germany; Dr. Markus Eickmann; Institut fuer Virologie, Hans-Meerweinstr. 2, 35043 Marburg, Germany; Dr. Christian Drosten; Bernhard-Nocht Institute for Tropical Medicine, National Reference Center for Tropical Infectious Diseases, Hamburg, Germany.

Reference: Drosten, C., et. al. (2003) Identification of a Novel Coronavirus in Patients with Severe Acute Respiratory Syndrome, New England Journal of Medicine. Vol 348,. PubMed ID to this reference is [12690091].

Classification

This is a description of a vertebrate virus at the isolate level.

ICTVdB Virus Code: 03.019.0.01.014.00.000.002. Virus accession number: SARSI016. Former accession number: 41C75363. NCBI Taxonomy ID: [242743].

Name, Synonyms and Lineage

Virus is assigned to species 03.019.0.01.014. Severe acute respiratory syndrome coronavirus. Virus is assigned to the genus 03.019.0.01. Coronavirus , family 03.019. Coronaviridae , order 03. Nidovirales.

Depositories and Collections

The isolate has been deposited at P3 facility, Institute for Medical Virology, University hospital of Frankfurt am Main, Paul Ehrlich Str. 40, 60506 Frankfurt Main, Germany.

Virion Properties

Morphology

Virions consist of an envelope, spikes, and a nucleocapsid.

Nucleic Acid

The genome is not segmented and consists of a single molecule of linear, positive-sense, single-stranded RNA. The complete genome is 29740 nucleotides long. The RNA has been fully sequenced and complete sequence is 29740 nucleotides long; sequence can be accessed at GenBank with the accession number [AY310120]. The 3'-terminus has a poly (A) tract 13 nucleotides in length. Reference to nucleotide sequence PubMed ID: [12917450].

Biological Properties

Natural Host Range

Viral hosts belong to the Domain Eucarya.

Domain Eucarya Kingdom Animalia.

Kingdom Animalia Phylum Chordata.

Phylum Vertebrata Subphylum Vertebrata.

Class Mammalia.

Class Mammalia Order Primates;
Family Hominidae; virus infects Homo sapiens (human).

Host and isolation details Virus was isolated from an adult. Virus was isolated from sputum sample.

General Symptoms in Animals Infection can affect the respiratory system, hematopoiesis, and musculo-skeletal system. General symptoms include fever and headache. Signs and symptoms include cough and dyspnoea or wheezing; myalgia; other: hypoxemia leukopenia (and lymphopenia).

Severity and Occurrence of Disease

Host 1: Infection is apparent and clinically expressed. Signs and symptoms { }{ } disappear soon after infection (Convalescence began on day 9).

Comments

This isolate has a genome identical to that of SARS CoV Frankfurt 1. The FRA patient is the wife of the Frankfurt 1 patient.

Contributor

Data have been submitted online to ICTVdB on 01-12-05 by
Sara Mullins
American Type Culture Collection
George Mason University
PW II, 10801 University Boulevard
Manassas, VA 20110
United States of America
Tel: + 703-365-2700.
Fax: + 703-365-2701.
Email: Sara Mullins.



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DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

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