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Descriptions are generated automatically from the ICTVdB database including links. Some descriptions are only very basic and links may point to documents that are not yet published on the Web.

00.073.0.01.017. Ndumu virus

Cite this publication as: ICTVdB Management (2006). 00.073.0.01.017. Ndumu virus . In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Table of Contents

Isolate Description

Isolation date: 03 March 1959.
Location: Northern Natal, Ndumu Game Preserve; South Africa.

Host of Isolate and Habitat Details
Source of isolate: mosquito (Aedes circumluteolus).

Collection and Isolation Details
Virus was isolated by unknown.

Reference to Isolation Report
Kokernot RH et al. (1961). Amer. J. Trop. Med. Hyg. 10: 383.

Biocontainment Level

Distribution of this virus falls under quarantine restrictions. It is recommended to handle this virus at the biocontainment level BSL-3.

Classification

This is a description of an invertebrate or vertebrate virus at the species level with data limited to classification details. If you have primary data on this virus, please submit them to ICTVdB using the online data entry systems or contact the ICTVdB management.

ICTVdB Virus Code: 00.073.0.01.017. Virus accession number: 73001017. Obsolete virus code: 73.0.1.0.017; superceded accession number: 73010017.
NCBI Taxon Identifier NCBI Taxonomy ID: 59302.

Name, Synonyms and Lineage

The taxon has the accepted ICTV name.

ICTV approved acronym: (NDUV). Virus is an ICTV approved species. Virus is of the genus 00.073.0.01. Alphavirus in the family 00.073. Togaviridae; not assigned to an order.

Virion Properties

Morphology

Virions consist of an envelope and a nucleocapsid. During their life cycle, virions have not been observed outside a cellular environment and have a cell-associated cycle. Virus capsid is enveloped (with a tight fitting membrane). Virions are spherical and measure about 70 nm in diameter. Surface projections are distinctive glycoprotein spikes composed of two virus proteins forming heterodimers that cover the surface. Capsid/nucleocapsid is round and exhibits icosahedral symmetry (T=4). The nucleocapsid is isometric and has a diameter of about 40 nm. Capsids appear round.

Nucleic Acid

The genome is not segmented and contains a single molecule of linear positive-sense, single-stranded RNA. The complete genome is about 11700 nucleotides long. Sequence can be accessed from GenBank; the RNA is partially sequenced. Sequenced genome has the accession number(s)
[AF398375]; [AF023281]; [U94600]. The 5'-end of the genome has a methylated nucleotide cap. The 3'-terminus has a poly (A) tract.

Reference to nucleotide sequence in PubMed: nucleotide sequences; complete genome sequences.

Proteins

The viral genome encodes structural proteins and non-structural proteins.

Antigenicity

The virus is serologically related to all viruses in the genus alphavirus.

Biological Properties

Natural Host

Virus infects during its life cycle arthropod and vertebrate hosts. Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Arthropoda and Chordata.

Phylum Arthropoda
Subphylum Hexapoda; Class Insecta; Subclass Pterygota (winged insects), Order Diptera.

Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.

Class Mammalia Order Rodentia.

Transmission and Vector Relationships

Virus is transmitted by a vector.

Vector Transmission:
Virus is transmitted by arthropods, insects.

Host:
Experimental host is susceptible to infection (suckling) mice. Experimentally infected hosts mainly show symptoms of death.

Geographical Distribution

The virus spreads in Africa.

List of Strains and Isolates in the Species

SA AR221D, SA Ar2204.

References

Pfeffer M, KinneyRM and Kaaden OR (1998). The alphavirus 3'-nontranslated region: size heterogeneity and arrangement of repeated sequence elements. Virology 240, 100-108

Powers AM, Brault AC, ShirakoY, Strauss EG, Kang W, Strauss JH and Weaver SC (2001). Evolutionary relationships and systematics of the alphaviruses. J. Virol. 75 , 10118-10131. The following generic references are cited in the most recent ICTV Report.

PubMed References.



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DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

ICTVdB and DELTA related References

Comments to ICTVdB Management
Last updated on 25 April 2006 by Cornelia Büchen-Osmond
Copyright © 2002    International Committee on Taxonomy of Viruses.    All rights reserved.


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