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Descriptions are generated automatically from the ICTVdB database including links. Some descriptions are only very basic and links may point to documents that are not yet published on the Web.

00.060.0.02.003.01.001.001. Bluetongue virus serotype 1 RSArr-01

Cite this publication as: ICTVdB Management (2006). 00.060.0.02.003.01.001.001. Bluetongue virus serotype 1 RSArr-01. In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Table of Contents

Isolate Description

Isolate designation: RSArr-01.
Isolation date: 03 March 2001.
Location: not specified; Afghanistan.

Depositories and Collections

The isolate has been deposited at a culture collection and an institution at Biocontainment Level Distribution of this virus falls under quarantine restrictions. It is recommended to handle this virus at the biocontainment level BSL-3.

Classification

This is a description of an invertebrate and vertebrate virus at the isolate level with data limited to classification details. If you have primary data on this virus, please submit them to ICTVdB using the online data entry systems or contact the ICTVdB management.

ICTVdB Virus Code: 00.060.0.02.003.01.001.001. Virus accession number: 60132403. Former accession number: 1051740678468.

Name, Synonyms and Lineage

Acronym(s): BTV-2/RSArr-01. Virus is assigned to species 00.060.0.02.003. Bluetongue virus; serotype 00.060.0.02.003.01. serotype 1. Virus is of the genus 00.060.0.02. Orbivirus; of the family 00.060. Reoviridae; not assigned to an order.

Virion Properties

Distinct viral structures are visible in thin sections of infected tissue. Particles contain nucleic acid which is encapsidated. Size and shape of virus has been determined by crystallography and determined by electron microscopy.

Virion Properties

Morphology

Virions consist of a capsid, a core, and a polymerase complex. During their life cycle, virions produce intracellular particles. Virus may be sequestered within inclusion bodies that are occluded by protein bodies. Virus capsid is not enveloped. Virions are not enveloped Virions can be released by budding and can acquire a transitory membrane when released from the host cell as a mature virion and although they are often associated with membranes in crude extracts. Capsid/nucleocapsid is round and exhibits icosahedral symmetry. The capsid is isometric.

Nucleic Acid

The genome is segmented and consists of ten segments of linear double-stranded RNA. The complete genome is Genome size based on electrophoretic migration and comparison of the fully sequenced genome of BTV-10 19216 nucleotides long. Segment 2 is fully sequenced. Segment 5. The 5'-terminal sequence has conserved regions.

Proteins

Proteins have been identified and been characterized and functions are assigned to them. Particles are made up of 7 proteins.

The viral genome encodes structural proteins and non-structural proteins. Virions consist of 7 structural protein(s) located in the outer capsid (VP2 and VP5), core (VP1, VP3, VP4, VP6 and VP7), subcore (VP1, VP3, VP4 and VP6).

Non-Structural Proteins: Virus-coded non-structural proteins have been isolated and identified by sequence analysis and 3 non-structural protein(s) are found. The virus codes for NS1: Tubule forming protein; NS2: Viral inclusion body matrix protein; NS3; Cell exit membrane protein; an RNA-dependent RNA polymerase. In addition to the polymerase, the virus codes for enzymes such as RNA transcriptase (The virion core-associated RNA polymerase (VP1(Pol)) has both replicase and transcriptase activities), or helicase (The internal subcore protein VP6(Hel) has helicase activity), or replicase (The virion core-associated RNA polymerase (VP1(Pol)) has both replicase and transcritase activities), or methyl-transferase (The internal subcore protein VP4(CaP) has two distinct transmethylase activities), or mRNA guanylyl transferase (The internal subcore protein VP4(CaP) has guanylyl transferase activities, 3 internal protein(s). The non-structural proteins are thought to be involved in the formation of a replicase complex for the minus strand synthesis and assembly of the capsid with the viral RNA to form the nucleocapsid.

Genome Organization and Replication

The process of intracellular uncoating of virions is understood. The viral core is delivered to the cell cytoplasm; site of mRNA transcription and RNA replication; causes the host cell protein synthesis to shut off.

By itself, genomic nucleic acid is not infectious; to be infectious, the viral nucleic acid does require add ional, essential virion-associated proteins.

Infection and Replication: Virus replication is initiated by the insect host (insect vector species, occurs in the midgut, proceeds to salivary glands, various organs, and various tissues; following Ingestion of intact virus particles, Infectious subviral particles (ISVP), or core particles. In the vertebrate host virus replication occurs in various organs and various tissues. Although severity of illness depends on route and dose, the majority of infections are Infection of the Insect vector has little observable effect on viability subclinical and temperate (severity depends on virus strain, host species and breed and varies from severe (fatal) to inapparent), or virulent. Infection involves a noncytocidal productive infectious cycle (Insect vector cells and ovine or bovine gamma delta T cells can be persistently infected).

Biological Properties

Natural Host

Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Arthropoda and Chordata.

Phylum Arthropoda
Subphylum Hexapoda; Class Insecta (Culicoides midges).

Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.

Class Mammalia Order Artiodactyla;
Family Bovidae: Subfamily Caprinae; virus infects Genus Ovis aries (sheep).

Geographical Distribution

The viral host lives in the atmosphere. The viral host is found in an agricultural environment; a populated environment.

Comments

This description has been compiled from data presented in research data.

References

PubMed References.
A description of the virus is found in The dsRNA Virus Collection at IAH Pirbright.

Contributor

Data have been submitted online to ICTVdB on 30-04-2003 by
Peter P. C. by
Mertens;
Pirbright Laboratory Institute for Animal Health;
Ash Road Pirbright;
Woking; Surrey; GU24 0ET;
UK;
Tel: + +44 1483 231017;
Fax: + +44 1483 232448;
email: [mailto] peter.mertens@bbsrc.ac.uk. Involved in the isolation of the virus was also Prof Peter Mertens; Pirbright Laboratory, Institute for Animal Health Ash Road, Pirbright, Woking, Surrey GU24 0ET UK. For further information on virus please contact the Study Group (SG) chair (see at


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DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

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Last updated on 25 April 2006 by Cornelia Büchen-Osmond
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