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00.060.0.01.004.01.003. Reovirus 3 strain Dearing

Cite this publication as: ICTVdB Management (2006). 00.060.0.01.004.01.003. Reovirus 3 strain Dearing. In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Table of Contents

Classification

This is a description of a vertebrate virus at the strain level.

ICTVdB Virus Code: 00.060.0.01.004.01.003. Virus accession number: 60001043. Obsolete virus code: 60.0.1.1.001; superceded accession number: 60011001.
NCBI Taxonomy Identifier Taxon ID: 10886.

Name, Synonyms and Lineage

Acronym(s): REOV-3. Virus is assigned to species 00.060.0.01.004. Mammalian orthoreovirus of the genus 00.060.0.01. Orthoreovirus; family 00.060. Reoviridae.

Virion Properties

Morphology

Virions consist of a capsid, a core, and a nucleoprotein complex. Virus capsid is not enveloped. Capsid/nucleocapsid is isometric with icosahedral symmetry and has a diameter of 81 nm. The capsid shells of virions are composed of two layers. All shells are usually present, or the outer shell is often lost during preparation. Capsids appear round. The capsid surface structure reveals a regular pattern with distinctive features. The capsomer arrangement is clearly visible. Surface projections are not present. Inner capsids core; have a diameter of 60 nm. Virus preparations contain one particle component. The core is spherical.

Only one species is recovered in preparations. Incomplete particles are common. They are devoid of nucleic acid characterized by capsids with dark centers in negative stain preparations, or incompletely assembled capsids.

Nucleic Acid

The Mr of the genome constitutes 15-20% of the virion by weight. The genome is monomeric; segmented and consists of ten segments of linear double-stranded RNA. The complete genome is 23700 nucleotides long. Sequence can be accessed from EBI-EMBL, or GenBank, or DNA Data Bank of Japan; the L1 is fully sequenced, complete sequence is 3854 nucleotides long and encodes minor core protein lambda-3. Sequence has the accession number [M24734]. L2 is fully sequenced, complete sequence is 3916 nucleotides long and encodes guanylyltransferase has the accession number [J03488]. L3 is fully sequenced, complete sequence is 1196 nucleotides long and encodes the major capsid surface protein sigma-3 has the accession number [M13139]. M1 has been fully sequenced, complete sequence is 2304 nucleotides long and encodes micron-2 protein, has the accession number [M27261]. M2 has been fully sequenced, complete sequence is 2207 nucleotides long and encodes mu-1/mu-1C has the accession number
[M19408]. M3 has been fully sequenced. Complete sequence is 2235 nucleotides long and encodes micron-NS protein has the accession number [M27262]. S1 has been fully sequenced, complete sequence is 1416 nucleotides long and encodes sigma-1 protein; has the accession number [M10262]. S2 has been fully sequenced, complete sequence is 1331 nucleotides long and encodes protein sigma-2; has the accession number [M25780]. S3 has been fully sequenced, complete sequence is 1198 nucleotides long and encodes putative non-structural protein sigma NS has the accession number [X01627]. S4 has been fully sequenced; complete sequence is 1196 nucleotides long and encodes major surface protein sigma-3; has the accession number [K02739 ]. The 5'-end of the genome has a methylated nucleotide cap; cap sequence type is m7G5ppp5'GmpNp. The multipartite genome is found in one type of particle only. Each virion contains a single copy of the genome.

GenBank records for nucleotide sequences; complete genome sequences.

Proteins

Proteins constitute about 80-85% of the particle weight.

The viral genome encodes structural proteins and non-structural proteins located in the capsid, inner capsid, and core.

Structural Proteins: Inner capsid protein lambda 1 (gene name L3), 60 subunits; has a molecular mass of 137353 Da (1233 AA, sequence has the accession number [P15024]; is a major core protein. Inner capsid protein mu-2 (gene name M1), subunits 60 (L2, has a molecular mass of 83276 Da (736 AA, sequence has the accession number [P12418]; is a minor structural protein. Inner capsid or core protein, sigma 2 (gene name S2), with subunits 150 (S2) has a molecular weight of 47161, is 418 AA long and has the accession number [P03525].

Lipids

Lipids are absent.

Biological Properties

Natural Host

Virus infects during its life cycle a single type of vertebrate host.
Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Chordata.

Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.

Class Mammalia Order Primates;
Family Hominidae.
Virus infects Homo sapiens (human).

Transmission and Vector Relationships

Virus is transmitted by a vector in a direct manner.

References

PubMed References.



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DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

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Last updated on 25 April 2006 by Cornelia Büchen-Osmond
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