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Descriptions are generated automatically from the ICTVdB database including links. Some descriptions are only very basic and links may point to documents that are not yet published on the Web.

00.052.0.01.001. Poliovirus

Cite this publication as: ICTVdB Management (2006). 00.052.0.01.001. Poliovirus. In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Table of Contents

Classification

This is a description of a vertebrate virus at the species level.

ICTVdB Virus Code: 00.052.0.01.001. Virus accession number: 52001001. Obsolete virus code: 52.01.0.001; superceded accession number: 52010001.
NCBI Taxon Identifier NCBI Taxonomy ID: 138953.

Name, Synonyms and Lineage

Virus is the type species of the genus 00.052.0.01. Enterovirus; family 00.052. Picornaviridae.

Virion Properties

Morphology

Virions consist of a capsid. Virus capsid is not enveloped, round with icosahedral symmetry. The isometric capsid has a diameter of 28-30 nm. Capsids appear round. The capsid consists of 12 capsomers.

Capsids can be penetrated by stain and some appear dark in the center. Incomplete particles are common. They are devoid of nucleic acid characterized by capsids with dark centers in negative stain preparations.





















3D image of virus reconstruction can be found at Institute for Molecular Virology, Madison, WI.

Mahoney type 1
native empty capsid, Mahoney type 1
Poliovirus-2 Lansing, complexed with antiviral angent SCH48973
Poliovirus 3, Sabin strain

Capsid structures, detailed structural and computational analysis are found in the Protein Data Bank (PDB) using VIPERdB, the VIrus Particle ExploreR Mahoney type 1; Mahoney type 1; native empty capsid, Mahoney type 1; Poliovirus-2 Lansing Complexed with antiviral angent SCH48973; Poliovirus 3, Sabin strain

Nucleic Acid

The Mr of the genome constitutes 29.2% of the virion by weight. The genome is not segmented and contains a single molecule of linear positive-sense, single-stranded RNA. The complete genome is 7400 nucleotides long, is fully sequenced. Sequence has the accession number
[V01150]. The 5'-end of the genome has a genome-linked protein (VPg). The 3'-terminus has a poly (A) tract.

GenBank records for nucleotide sequences; complete genome sequences.

Proteins

The viral genome encodes structural proteins located in the capsid.

Structural Proteins: Capsid protein VP1, VP2, VP3, AND VP4. With 60 copies per virion; capsid protein is the product of the polyprotein P3C; capsid protein is involved in viral encapsidation; which possess(es) polypeptide is a protease that cleaves at certain Q/G sites in the polyprotein. It may be a cystein protease.

Lipids

Lipids are usually absent, but sometimes present in minute amounts as sphingosine-like molecules (i.e. some strains may carry 60 molecules each) and are located in the inner surface of the capsid. Polypeptide 1A (VP4) has a molecule of myristic acid covalently attached to the amino terminal glycine.

Genome Organization and Replication

By itself, genomic nucleic acid is infectious.

Biological Properties

Natural Host

Virus infects during its life cycle a single type of vertebrate host.
Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Chordata.

Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.

Class Mammalia Order Primates;
Family Hominidae.
Virus infects Homo sapiens (human).

References

PubMed References.

Images

Taxon images: • Poliovirus - receptors http://bilbo.bio.purdue.edu/~baker/projects/picorna/polio/polio.html. • Poliovirus http://bilbo.bio.purdue.edu/~baker/projects/picorna/polio/polio.html.



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DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

ICTVdB and DELTA related References

Comments to ICTVdB Management
Last updated on 25 April 2006 by Cornelia Büchen-Osmond
Copyright © 2002    International Committee on Taxonomy of Viruses.    All rights reserved.


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