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Descriptions are generated automatically from the ICTVdB database including links. Some descriptions are only very basic and links may point to documents that are not yet published on the Web.

00.026.0.03. Hepacivirus

Cite this publication as: ICTVdB Management (2006). 00.026.0.03. Hepacivirus. In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Classification

This is a description of a vertebrate virus at the genus level.

ICTVdB Virus Code: 00.026.0.03. Virus accession number: 026003GE. Obsolete virus code: 26.0.3.; superceded accession number: 26030000.
NCBI Taxon Identifier NCBI Taxonomy ID: 11102.

Name, Synonyms and Lineage

Virus is of the family 00.026. Flaviviridae.

Morphology

Virions consist of an envelope and a nucleocapsid. Virus capsid is enveloped by a detergent sensitive lipoprotein. Virions are spherical and measure estimated to be 50 nm in diameter. Capsid/nucleocapsid is round and exhibits polyhedral symmetry. The core is isometric and has a diameter of about 30 nm.

Physicochemical and Physical Properties

Virions have a buoyant density in CsCl of 1.07-1.22 g cm-3; sucrose of 1.09-1.11 g cm-3. The sedimentation coefficient is greater than or equal to 150 S20w. Under in vitro conditions virions are stable in alkaline environment of pH 8. Virions are sensitive to treatment with organic solvents and detergents.

Nucleic Acid

The genome is not segmented and contains a single molecule of linear positive-sense, single-stranded RNA. The complete genome is 9600 nucleotides long. The 5'-terminus has a long non-coding region; that contains an internal ribosomal entry site; is about 340 nucleotides in length; 5'-end of the genome does not have cap. The 3'-terminus has a long non-coding region; conserved nucleotide sequences and a sequence variable region; sequence has highly conserved regions; sequence has about 100 nucleotides in length. The 3'-terminus has variable regions. The 3'-terminus has about 50 nucleotides in length; a polypyrimidine region; averaging about 100 nucleotides in length (but variable in length). The 3'-terminus has no poly (A) tract, or a poly (A) tract (in some isolates). The genome has an intergenic poly (A) region.

GenBank records for nucleotide sequences; complete genome sequences.

Proteins

The viral genome encodes structural proteins and non-structural proteins. Virions consist of have not been established by conventional biochemical methods, however 3 structural protein(s) (putative proteins are encoded at the 5' end).

Lipids

Lipids are present (but not demonstrated directly) and are located in the envelope (on the basis of solvent sensitivity).

Genome Organization and Replication

By itself, genomic nucleic acid is infectious.

Translation: The genome replicates in the cytoplasm.

Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Chordata.

Phylum Vertebrata
Subphylum Vertebrata; Class Mammalia.

Class Mammalia Order Primates;
Family Hominidae.
Virus infects Homo sapiens (human).

Transmission and Vector Relationships

Virus is not transmitted by a vector.

Geographical Distribution

The virus is probably distributed worldwide.

Taxonomic Structure of the Genus

Type species 00.026.0.03.001. Hepatitis C virus .

Species in the Genus

List of Species in the Genus.

Data Sources and Contributions

The description has been compiled from data in the ICTV Report presented by Wengler G, Bradley DW, Collett MS, Heinz FX, Schlesinger RW, Strauss JH.

References

The following generic references are cited in the most recent ICTV Report.

PubMed References. Information about this virus have been posted on the web by a health support group (


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DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia. ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses by Dr Cornelia Büchen-Osmond is written in DELTA. The virus descriptions in ICTVdB are coded by, or using data from experts in the field of virology or members ICTV. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations are automatically generated and formatted for display on the Web from the descriptions in DELTA-format. The description has been generated automatically from DELTA files. DELTA - DEscription Language for TAxonomy developed by Dr Mike Dallwitz, Toni Paine and Eric Zurcher, CSIRO Entomology, Canberra, Australia.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

ICTVdB and DELTA related References

Comments to ICTVdB Management
Last updated on 25 April 2006 by Cornelia Büchen-Osmond
Copyright © 2002    International Committee on Taxonomy of Viruses.    All rights reserved.


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