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Descriptions are generated automatically from the ICTVdB database including links. Some descriptions are only very basic and links may point to documents that are not yet published on the Web.

00.026.0.01. Flavivirus

Cite this publication as: ICTVdB Management (2006). 00.026.0.01. Flavivirus. In: ICTVdB - The Universal Virus Database, version 4. Büchen-Osmond, C. (Ed), Columbia University, New York, USA

Cite this site as: ICTVdB - The Universal Virus Database, version 4. http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/

Classification

This is a description of a vertebrate virus at the genus level.

ICTVdB Virus Code: 00.026.0.01. Virus accession number: 026001GE. Obsolete virus code: 26.0.1.; superceded accession number: 26010000.
NCBI Taxon Identifier NCBI Taxonomy ID: 11051.

Name, Synonyms and Lineage

Synonym(s): Arbovirus group B. Virus is of the family 00.026. Flaviviridae.

Morphology

Virions consist of an envelope and a nucleocapsid. Virus capsid is enveloped. Virions are spherical and measure 40-50 nm in diameter. Surface projections are small spikes surrounded by a prominent fringe. Surface projections are 6 nm long (which are constructed from two viral proteins: E and preM in the case of the cell-associated virus particles, or E and m in the case of extracellular particles). Capsid/nucleocapsid is round and exhibits polyhedral symmetry. The core is isometricand has a diameter of 30 nm.

Capsids can be penetrated by stain and some appear dark in the center.

Physicochemical and Physical Properties

The molecular mass (Mr) of virions is 60 x 10⁶. Virions have a buoyant density in CsCl of 1.22-1.24 g cm^-3. The sedimentation coefficient is 170-210 S_20w. The thermal inactivation point (TIP) is at 40°C. Under in vitro conditions virions are stable in alkaline environment of pH 8. Virions are sensitive to treatment with organic solvents and detergents.

Nucleic Acid

The genome is not segmented and contains a single molecule of linear positive-sense, single-stranded RNA. The complete genome is 10488-10976 nucleotides long. The 5'-end of the genome has a methylated nucleotide cap. The 3'-terminus has no poly (A) tract, or a poly (A) tract (in case of some strains of tick-borne encephalitis complex of flaviviruses).

GenBank records for nucleotide sequences; complete genome sequences.

Proteins

The viral genome encodes structural proteins and non-structural proteins. Virions consist of of extracellular virus 3 structural protein(s), or 4 structural protein(s) (in case of cell-associated virus).

Lipids

Lipids are present and located in the envelope. Virions are composed of 17% lipids by weight. The composition of viral lipids and host cell membranes are similar. The lipids are of host origin and are derived from host cell membranes.

Genome Organization and Replication

By itself, genomic nucleic acid is infectious.

Translation: The genome replicates in the cytoplasm.

Antigenicity

Antigenic determinants may be found on envelopes; correspond to each of the major virion proteins E. Although different antigenic determinants have different specificities, the antigenic determinants are in general type-specific and serogroup-specific. The type-specific antigenic determinants are involved in antibody mediated neutralization. Antigenic specificity of the virion can be determined by ELISA tests, or RIA tests, or immunodiffusion tests, or neutralization tests, or enhancement of infectivity assays.

Biological Properties

Natural Host

Virus infects during its life cycle arthropod and vertebrate hosts. Domain
Viral hosts belong to the Domain Eucarya.

Domain Eucarya
Kingdom Animalia.

Kingdom Animalia
Phylum Arthropoda and Chordata.

Phylum Vertebrata
Subphylum Vertebrata.

Class Mammalia and Aves.

Class Mammalia Order Marsupialia, Primates, Carnivora, Perissodactyla, and Artiodactyla;
Family Hominidae; virus infects Homo sapiens (human).

Transmission and Vector Relationships

Virus is usually transmitted by a vector, or not transmitted by a vector.

Vector Transmission:
Virus is transmitted by arthropods. Virus usually replicates in the vector.

Histopathology: Virions are found in the cytoplasm.

Geographical Distribution

The virus is probably distributed worldwide.

Taxonomic Structure of the Genus

Type species 00.026.0.01.001. Yellow fever virus .

Species in the Genus

List of Species in the Genus.

Tentative Species in the Genus

Tentative Species in the Genus.

Data Sources and Contributions

The description has been compiled from data in the ICTV Report presented by Wengler G, Bradley DW, Collett MS, Heinz FX, Schlesinger RW, Strauss JH.

References

The following generic references are cited in the most recent ICTV Report.

PubMed References.

The description has been generated automatically from DELTA files.

ICTVdB - The Universal Virus Database, developed for the International Committee on Taxonomy of Viruses (ICTV) by Dr Cornelia Büchen-Osmond, is written in DELTA. The virus descriptions in ICTVdB are coded by ICTV members and experts, or by the ICTVdB Management using data provided by the experts, the literature or the latest ICTV Report. The character list is the underlying code. All virus descriptions are based on the character list and natural language translations from the encoded descriptions are automatically generated and formatted for display on the Web.

Developer of the DELTA software: M. J. Dallwitz, T. Paine and E. Zurcher

ICTVdB and DELTA related References

Comments to ICTVdB Management
Last updated on 25 April 2006 by Cornelia Büchen-Osmond
Copyright © 2002 International Committee on Taxonomy of Viruses. All rights reserved.

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